Syphilis treatment doxycycline – syphilis treatment doxycycline dosage

syphilis treatment doxycycline? There are many questions concerning syphilis treatment doxycycline . As earlier said, Syphilis can be treated but remember prevention will always keep you save. We equally advise you to meet your doctor frequently for check-up, in case of any disease like syphilis. syphilis treatment with doxycycline and dosage.

We are going to Discuss the following

syphilis treatment doxycycline

Dealing with sex partners

Primary and secondary syphilis

Syphilis treatment doxycycline

Syphilis treatment doxycycline

From research,Of the 118 syphilis cases with available treatment outcome data, 94 (79.7%) were treated with doxycycline at 100 mg twice daily for 14 days for early syphilis and 24 (20.3%) were treated with doxycycline at 100 mg twice daily for 28 days for late syphilis. The group with late latent syphilis had a lower median basic serum TRUST titer than the group with early latent syphilis (median TRUST titer, 1:16 versus 1:64). The two treatment groups were generally similar with regard to sociodemographic and behavioral characteristics.

The research from ASM journals also shows

All the clinical symptoms of primary and secondary syphilis resolved after treatment. The total serological response rates were 92.4% (109/118) for the 118 PP patients. The distribution of the serological response according to the clinical stage of syphilis is shown in At 12 months, the serological response rate was 100.0% (7/7) in patients with primary syphilis, 96.9% (62/64) in patients with secondary syphilis, 91.3% (21/23) in patients with early latent syphilis, and 79.2% (19/24) in patients with late latent syphilis. Among these patients, the seroreversion rate was 85.7% (6/7) in patients with primary syphilis, 39.1% (25/64) in patients with secondary syphilis, 47.8% (11/23) in patients with early latent syphilis, and 25% (6/24) in patients with late latent syphilis. The median TRUST titer decrease was 16-fold at 12 months. The total serological response rate was 66.9% (109/163) for all ITT patients.

Dealing with Sex Partners

Sexual transmission of T. pallidum is thought to occur only when mucocutaneous syphilitic lesions are present. Such manifestations are uncommon after the first year of infection. Persons exposed sexually to a person who has primary, secondary, or early latent syphilis should be evaluated clinically and serologically and treated according to the following recommendations:

  • Persons who have had sexual contact with a person who receives a diagnosis of primary, secondary, or early latent syphilis within 90 days preceding the diagnosis should be treated presumptively for early syphilis, even if serologic test results are negative.
  • Persons who have had sexual contact with a person who receives a diagnosis of primary, secondary, or early latent syphilis >90 days before the diagnosis should be treated presumptively for early syphilis if serologic test results are not immediately available and the opportunity for follow-up is uncertain. If serologic tests are negative, no treatment is needed. If serologic tests are positive, treatment should be based on clinical and serologic evaluation and stage of syphilis.
  • In some areas or populations with high rates of syphilis, health departments recommend notification and presumptive treatment of sex partners of persons with late latent syphilis who have high nontreponemal serologic test titers (i.e., >1:32), because high titers might be indicative of early syphilis. These partners should be managed as if the index case had early syphilis.
  • Long-term sex partners of persons who have late latent syphilis should be evaluated clinically and serologically for syphilis and treated on the basis of the evaluation’s findings.
  • The following sex partners of persons with syphilis are considered at risk for infection and should be confidentially notified of the exposure and need for evaluation: partners who have had sexual contact within 1) 3 months plus the duration of symptoms for persons who receive a diagnosis of primary syphilis, 2) 6 months plus duration of symptoms for those with secondary syphilis, and 3) 1 year for persons with early latent syphilis.

Primary and Secondary Syphilis

Treatment

Parenteral penicillin G has been used effectively to achieve clinical resolution (i.e., the healing of lesions and prevention of sexual transmission) and to prevent late sequelae. However, no comparative trials have been conducted to guide the selection of an optimal penicillin regimen. Substantially fewer data are available for nonpenicillin regimens.

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